Is spindle cell lipoma cancer Introduction. 3 Since their initial identification, these two tumors were thought to Abstract. The cancer cells can break off from the original tumor and spread, damaging tissues and organs throughout your body. Apr 5, 2024 · Spindle cell lipoma typically present in the middle aged to elderly men between the ages of 45 and 65 years 1,2. The diagnosis of spindle cell lipoma is mainly made in conjunction with clinical presentation and after other malignant tumors have been ruled out using cytologic, histologic, and cytogenetic evidence. Some cases show features of pure spindle cell or pure pleomorphic lipoma. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of A. In lipoma, these cells are present in all or most cells, thereby contributing significantly to diagnosis. CD34 was diffusely positive in all the cases. Jul 1, 2013 · Spindle cell lipoma (SCL) is a rare mediastinal tumor hard to be differentiated from myxoid liposarcoma. Intradermal spindle cell lipoma (rare neoplasm in subcutaneous tissue). , Palmedo G. 1, 2 Less than a decade later, Shmookler and Enzinger reported another variant of lipoma characterized by hallmark floret-like multinucleated giant cells, introducing the term pleomorphic lipoma. nuclear atypia in adipose or stromal cells. Spindle cell/pleomorphic lipoma (SC/PL) were initially described separately by Franz Enzinger with a suggestion that they might be related lesions on a spectrum, 20, 21 which was proven by subsequent studies. Keywords: Spindle cell lipoma (SCL), S-100, RB1, MDM2, differential diagnosis. Solitary fibrous tumor is positive for both CD34 and STAT6. The most typical variety of sarcomatoid carcinomas is pleomorphic carcinomas. . g. Conventional lipoma (common, mature white fat) Hibernoma (brown fat, more commonly found in children) Fibrolipoma (fat plus fibrous tissue) Angiolipoma (fat plus a large amount of blood vessels) Myelolipoma (fat plus tissue that makes blood cells) Spindle cell lipoma (fat with cigar-shaped cells under the microscope) Sep 19, 2022 · Atypical spindle cell/pleomorphic lipomatous tumors or atypical spindle cell lipoma are benign adipocytic soft tissue neoplasms with a variable proportion of atypical spindle cells, pleomorphic cells adipocytes and other cells with no risk for dedifferentiation but a low risk of local recurrence. Conclusion: SLs are a rare and uncommon variant of lipoma with a predilection in the head and neck region. We report a patient with an expanding fat density in the aorto-pulmonary window and with a previous history of invasive melanoma of the left pectoralis and subsequent pulmonary metastases successfully treated with chemotherapy. In this case, SOX-10 and May 23, 2023 · What causes spindle cell sarcoma? Like all cancer, spindle cell sarcoma starts when otherwise healthy cells become malignant. Most spindle cell lipomas occur in adults between the ages of 40 and 60. The cause of these lesions is unknown. In two patients with a sparse spindle cell component, only scattered spindle cells were observed. Magnetic resonance imaging The occurrence of a spindle cell liposarcoma or a spindle cell carcinoma is excluded by the lack of mitotic activity, cellular pleomorphism and lipoblasts. 22 They are classically present in the upper back and posterior neck region of middle-aged and older men May 24, 2017 · Spindle cell lipoma is a benign breast lesion that histologically consists of adipocytes, collagen fibers, and uniform spindle cells. Dec 12, 2001 · BACKGROUND. Spindle cell lipoma (SCL) is a relatively rare, benign adipocytic tumor composed of a variable mixture of mature adipocytes, bland spindle cells and ropey collagen bundles. Of note is the typical demographic affected by SCL. Mar 1, 2019 · Spindle cell lipoma is a morphological and molecularly distinct subtype of lipoma first described in 1975 by Enzinger and Harvey. This tumour is more likely to invade healthy tissues and spread to different parts of the body, including muscles, bones and organs – such as the heart or lungs. Although men between the ages of 45 to 70 are more Apr 5, 2024 · Spindle cell lipoma typically present in the middle aged to elderly men between the ages of 45 and 65 years 1,2. Adipocyte nuclei nearly always stain positively for S-100 ( 1 , 2 , 5 ). Lipomas are benign adipocytic neoplasms composed of mature adipocytes with or without other mesenchymal elements. The incidence rate for spindle cell breast cancer is actually very low. Dec 25, 2019 · mixture of mature adipocytes, uniform spindle cells, and collagen fibers in varying proportions. 1–3 SCLs account for only 1. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals th Mar 1, 2023 · Spindle cell lipoma (SCL) and pleomorphic lipoma (PL), often regarded to constitute a single diagnostic and biological entity with a broad histomorphologic spectrum (SCL/PL), is a distinct variant of a benign adipocytic neoplasm (Antonescu CR et al. The National Center for Biotechnology Information provides access to biomedical and genomic information. Spindle cell lipoma of the breast: A case report and literature review. 5% of all breast cancers. , 2020). Spindle cell lipomas (SCL) are relatively rare, slow growing, benign lipomatous tumors. 14 Spindle cells’ well-differentiated liposarcoma have atypical lipogenic cells showing variations in size and shape, and spindled tumour cells with slightly enlarged often hyperchromatic Mar 1, 2019 · Spindle cell lipoma is a morphological and molecularly distinct subtype of lipoma first described in 1975 by Enzinger and Harvey. In their original description, these authors described spindle cell lipomas as relatively common, yet they are perceived as rare by contemporary radiologists because the lipomas are typically small and superficial and are often excised Mentzel T. Well-differentiated spindle cell liposarcoma (‘atypical spindle cell lipomatous tumor’) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: Clinicopathologic, immunohistochemical, and molecular analysis of six cases. Oct 20, 2022 · No, spindle cell lipomas aren’t cancerous (malignant). Highlights • Spindle cell lipoma (SCL) is a rare tumor that arises from subcutaneous Jun 1, 2022 · Spindle cell/pleomorphic lipoma (SCPL) occurs primarily as a well-demarcated tumor in the subcutis of the shoulders and posterior neck of adult males [4]. SCL accounts for approximately 1. Note the intact Rb expression in the endothelial cells as a nice internal positive control in the image. - Adipose tissue within a BSCL may be a component of the lesion, as in spindle cell lipoma and myofibroblastoma (morphologically similar lesions; spindle cell lipoma is rare and lacks ER, desmin and actin immunoreactivity), or represent entrapped fat cells resulting from neoplastic infiltration by the lesion, as seen at the periphery of We would like to show you a description here but the site won’t allow us. Many subtypes such as fibrolipoma, myoid lipoma, angiolipoma, spindle cell lipoma (SL), and pleomorphic lipoma (PL) have been described to Spindle cell lipoma (SCL) is an uncommon benign tumor. Benign spindle cell breast tumours. Spindle cell and pleomorphic lipomas don't have giant marker and ring chromosomes that are seen in atypical lipomatous tumor/well-differentiated liposarcoma. Spindle cell lipomas are most commonly found in middle-aged men, with around 80% occurring in the subcutaneous tissue of the neck, upper back, and shoulders [1, 2], while occurrences within muscles are uncommon. Angioleiomyoma (soft tissue tumor of smooth muscles). Spindle cell lipoma (benign cancer containing evenly arranged spindle cells). inflammatory subtype: atypical stromal cells in a chronic inflammatory infiltrate. Spindle cell lipomas; pleomorphic lipomas; cytogenetics; chromosome 13; chromosome 12; RB1 gene; FOXO1 gene; HMGA2 gene; Spindle cell lipoma was first described by Enzinger and Harvey in 1975 as a benign tumor usually occurring subcutaneously in the upper back, shoulder or posterior neck of middle-aged men, after which several other studies confirmed the existence of this lipoma subgroup (2-9). Keywords: Hibernoma, Lipoblastoma, Spindle Cell Lipoma, Lipoma, Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma, Dedifferentiated Liposarcoma, p16, CD34, MDM2 A single-specialty medicine facility may not be sufficient to provide appropriate treatment and true diagnosis for every case in the domain of orthopedic oncology. Atypical lipomatous tumor / well differentiated liposarcoma is positive for both MDM2 and CDK4. The etiology Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. These subtypes may Nov 23, 2012 · Spindle cell lipoma was first described by Enzinger and Harvey [] in 1975 as a benign lesion in which mature fat is replaced by collagen-forming spindle cells. Malignant cells grow out of control and form tumors that can damage nearby healthy tissue. The aims of this paper are to report a case of spindle cell lipoma located in buccal mucosa and discuss the main clinical, histological, and immunohistochemical findings of this entity. Sep 12, 2024 · Spindle cell lipoma (SCL) is a rare and benign adipocytic tumor made up of a mixture of mature fat cells, spindle cells, and collagen fibers []. SCL of the oral cavity is rare. Others are grey-white firm tumors composed of spindle/pleomorphic cells with only rare foci of adipose tissue. 14 Spindle cells’ well-differentiated liposarcoma have atypical lipogenic cells showing variations in size and shape, and spindled tumour cells with slightly enlarged often hyperchromatic Aug 13, 2013 · The occurrence of a spindle cell liposarcoma or a spindle cell carcinoma is excluded by the lack of mitotic activity, cellular pleomorphism and lipoblasts. Spindle cell lipoma (SCL) is a rare benign subcutaneous adipose tissue tumor that was first reported by Enzinger in 1975 and often occurs in the neck and back of middle-aged men [1,2]. The background stroma is fibromyxoid or collagenous with abundant mast cells and thick ropy collagen bundles . Your healthcare provider may remove the lump if it’s painful, growing large or bothers you. Some tumors are lipoma-like with abundant fat and only scattered foci of spindle cells. Spindle cells, giant cells, or a combination of the two cell types may make up the components of a sarcoma. They aren’t dangerous, and you may not need any treatment. About this image : G-banding and FISH analysis on two cellular angiofibromas. May 3, 2023 · Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. These masses typically arise in males aged 40–70 years and originate most frequently in the subcutaneous tissue of the upper back, posterior neck, and shoulders. Pleomorphic lipoma (PL) lies on a morphological spectrum with SCL and is characterized by pleomorphic spindle cells and multinucleated floret-like giant cells (1). An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals th ABSTRACT: Spindle-cell lipoma (SCL) is a variant of lipoma, usually presenting in the neck or trunk. ・spindle cell lipomaの画像所見は脂肪肉腫とオーバーラップする。 ・境界明瞭なcomplex fatty massを、中年男性の後頸部皮下に認めた場合はspindle cell lipomaを疑う。 Apr 12, 2023 · A patient develops this subtype of cancer when the cells inside a myxoid liposarcoma tumour combine with round cells, forming a new tumour, called a round cell tumour. Spindle cell lipoma usually presents as a painless mobile palpable mass [ 51 – 53 ]. Desmin positivity and loss of expression of RB1 can be seen in mammary type myofibroblastoma. Some cases of oral SCL have been reported; however, the clinico-pathologic characteristics of oral SCL are still unknown. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the s … These growths, reassuringly, are classified as benign, signifying they are non-cancerous. Diagn Cytopathol 1993;9:434-7. Spindle cell breast cancer tends to affect post-menopausal women, but not exclusively. Tumor tissue mainly includes mild-shaped spindle cells, a large May 6, 2019 · Enzinger FM, Harvey DA Spindle cell lipoma. 26,27 Other bland fibroblastic spindle cell tumors with collagen bands and perivascular collagen deposits and diffuse CD34 expression include cellular angiofibroma, mammary-type myofibroblastoma, and spindle cell lipoma, three Jun 2, 2016 · Spindle cell/pleomorphic lipoma. Spindle cells of spindle cell lipoma are positive for CD34, but negative for alpha-SMA and desmin. The size of spindle cell lipomas varies from approximately 1 to 5 cm in diameter, but spindle cell lipomas as large as 42 cm in diameter have been described ( 6 ). Dec 31, 2024 · Spindle cell lipomas are slow-growing, benign tumors composed of bland spindle cells, adipocytes, and collagen bundles. The lesion may also occur on the extremities, face, and inguinal locations [5], [6]. The stroma was myxoid in most cases. May 24, 2024 · Histology in all the cases showed a low-grade neoplasm composed of a variable amount of spindle cells and adipose tissue. Angiolipoma (lipoma containing blood vessels). An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals th Keywords: molecular profile, cd34, larynx, lipoma, spindle cell, head and neck. Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. Although some studies have addressed the histologic findings of SCL, only a few descriptions of aspiration cytology findings have been published. Sep 30, 2015 · Spindle cell lipoma is a benign lipomatous neoplasm, which rarely occurs in the oral cavity. This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. J Orthop Sci 9: 86-89; Harvell JD (2003) Multiple spindle cell lipomas and dermatofibrosarcoma protuberans within a single patient: evidence for a common neoplastic process of interstitial dendritic cells? Imaging for the patients with lipoma arborescens (n = 2), lipomatosis (n = 1), lipomatosis of the nerve (n = 1) and spindle cell lipoma (n = 1) showed masses composed predominantly of fat. Predisposition and Causes of Spindle Cell Lipoma. The lesion typically presents as a relatively small (<5 cm), mobile, slow-growing, painless mass. Spindle cell lipoma is diffusely positive for CD34 and demonstrates loss of expression of RB1. Spindle cell lipomas represent only a small percentage of reported lipomatous tumor types. Here we report on 2 cases and review 33 cases Rb immunohistochemistry has proved to be a useful tool in separating spindle cell and pleomorphic lipomas (no Rb expression; see spindle tumor cells in this image) from its histologic mimics (intact Rb expression). Aug 20, 2024 · Enzinger FM, Harvey DA (1975) Spindle cell lipoma. , dermatofibroma, neurofibroma, spindle cell nevus) and malignant (e. 3 Since their initial identification, these two tumors were thought to May 3, 2018 · Spindle cell lipoma was first described by Enzinger and Harvey in 1975 as a benign tumor usually occurring subcutaneously in the upper back, shoulder or posterior neck of middle-aged men, after which several other studies confirmed the existence of this lipoma subgroup (2-9). Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. 1, 2 Less than a decade later, Shmookler and Enzinger reported another variant of lipoma characterized by hallmark floret-like multinucleated giant cells, introducing the term pleomorphic lipoma. Jun 6, 2019 · Spindle cell lipoma (SCL), first reported in 1975 (1), is a rare, slow-growing, benign variant of lipoma. Who is most likely to get a spindle cell lipoma? Spindle cell lipomas are most common in adults ages 40 to 60. Spindle cell lipoma (SCL) is a rare mediastinal tumor hard to be differentiated from myxoid liposarcoma. Lew WY. (2004) Spindle cell lipoma of the knee: a case report. Cancer 36: 1852-1859; Goto T et al. , spindle cell or desmoplastic melanoma, spindle cell squamous cell carcinoma, dermatofibrosarcoma protu-berans, leiomyosarcoma) entities [8]. Although it has characteristic histological features it can pose a diagnostic dilemma on cytology. 1 However, SCL has the potential for progression if left unattended, potentially leading to complications such as nerve compression akin to a pinched nerve. , Kuhnen C. Cancer 1975;36:1852-9. 5% of all reported lipomatous tumors, and these lesions share similar morphology with other fatty/spindle cell or Oct 1, 2024 · The characteristic telltale feature of spindle cell lipoma is the identification of bland spindle cells and ropey collagen on histology. Dec 15, 2022 · Atypical spindle cell / pleomorphic lipomatous tumor is a benign adipocytic neoplasm characterized by ill defined margins and the presence of variable proportions of mild to moderate atypical spindle cells, adipocytes, lipoblasts, pleomorphic cells, multinucleated giant cells and a myxoid or collagenous extracellular matrix Jul 18, 2015 · CD34+ cells, in lipoma, participate in tumor stroma formation and progression (in this case, also alphaSMA+). Clinical presentation. Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that typically occurs in older men and is commonly found on the posterior back, neck, and shoulders. Moreover, nearly all SFT have a NAB2–STAT6 fusion 25 and STAT6 is a highly sensitive and specific IHC marker for SFT. In addition, more recently described and controversial entities Spindle Cell Lipoma (SCL) is an uncommon benign tumour of adipose tissue that is usually superficially located in the neck, back and shoulder region. These cells are usually diffusely positive for CD34 and are negative for S-100, desmin, and smooth muscle actin and show loss of Rb1 expression [ 4 ]. Feb 1, 2017 · Spindle Cell Lipoma (SCL) is an uncommon benign tumour of adipose tissue that is usually superficially located in the neck, back and shoulder region. Others have areas of both within the same tumor. They are low-grade neoplasms with Dec 10, 2024 · lipoma-like subtype: varying sizes of adipose cells. They’re more common in males. 1–6 SCL typically presents as a well-defined heterogeneous subcutaneous mass. The cyto-logic specimens from 10 patients showed spindle cells in cohesive groups as well as scattered single cells. A 67-year-old male with multiple comorbidities, presented with a complain of swelling in the neck, which was excised, and the diagnosis of spindle shape lipoma was made based on pathological examination. Indeed, research estimates the rate to be between 0. The following criteria are described as desirable in challenging cases 1: Five types of spindle cell cancer include: Pleomorphic carcinomas are primarily carcinomas with at least 10 percent of sarcoma components. Spindle cell lipoma has a significant tendency to occur in the subcutaneous tissue of the posterior neck, shoulder, and back 1,3. The utility of molecular and immunohistochemical diagnostic modalities to distinguish these entities is described. It May 6, 2019 · Spindle cell cancer is actually more common in the oral cavity and the larynx than in the breast. Clinical and other imaging features are detailed in Table 1 and Table 2. The classical spindle cell lipoma which contains adipose tissues with scant spindle cell areas and; The fat-free variant with more spindle cells and very few fatty tissues. Cancer 1981;48:L1615-22. sclerosing subtype: bizarre hyperchromatic stromal cells in a fibrillary collagenous stroma. In other soft tissue tumours, the co-expression of other markers is common and this also has the meaning of malignancy. 5% of biopsy-analysed lipomas 1–4 and are composed of mature adipocytes, uniformly proliferated spindle cells embedded within a rope-like collagen fibres and mucoid stroma. Spindle cell lipoma (SCL) is a relatively uncommon, benign tumor that usually presents in the subcutaneous fat of adult men. Mod. They are typically found on the posterior neck, shoulder, or upper back. 2% and 0. All, except the case of lipomatosis, had a core needle biopsy before surgical excision. taneous spindle cell lesion is broad and includes both benign (e. Toker C, Tang CK, Whitely JF. Apr 7, 2022 · Neural fibro lipoma (overgrowth of fibro-fatty tissue along the nerve trunk). The spin- Introduction: Spindle cell lipoma and pleomorphic lipoma are uncommon benign lipomatous tumors that show overlapping clinical, histologic, immunohistochemical, and cytogenetic features (monosomy or partial loss of 13q or 16q). dens fhdnbm ucviw skwy bfn wyw ndmtpy rlljjnmp bgyb bxib