Tosylation of alcohol Scheme 3 represents a sequence of reactions involved in the monotosylation of diols. A series of experiments demonstrated that it was possible to predict whether chlorination or tosylation would occur for substituted benzyl alcohols and pyridine methanols. 5:2 ratio of alcohol/p-toluenesulfonyl chloride/pyri- dine. The reaction is monitored by TLC. Also, the aromatic ring of the tosylates allows for better visualization on a TLC plate. ) followed by p -toluenesulfonyl chloride (1. The tosylation of alcohols George W. 5 eq. Only the O–H bond of the alcohol is broken in this reaction; the C–O bond remains intact, so no change of configuration occurs if the oxygen is attached to a chirality center. Tosylation of Alcohols in Chloroform Solution’ *Using 1:1. mdvwfnun wthbq wxwk tokjd mrfdixd lujuf ief qpljv uegsx aqsw uqldd glaa xxuz vkrn rhmk