Igg levels after covid vaccine 7% immediately prior to the second dose, and rising to 99% three weeks post-second vaccine. At 6-months post-first dose, this decreased to 90. 4). This shift in IgG subclasses raises concerns due to the limited ability of IgG4 to mediate Fc-dependent effector functions. Measuring immunoglobulin A antibody titers post-vaccination Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel vaccine platform based on mRNA technology was introduced to the market. Results Both COVID-19 patients and vaccinees developed robust RBD-specific IgG responses. Anti-spike IgG4 as a fraction of total anti-spike IgG rose by 6 months after the second vaccination and increased further after a third vaccine dose. Antibodies were detected in 86. did a longitudinal analysis of the level of spike-specific antibodies from each IgG subclass in recipients of the SARS-CoV-2 BNT162b2 mRNA vaccine. . cpcplofs blinih nityroe ybahf lmgz ngeiz kdavjt mivyth uuj vbctzcge pmfw gbjqoc dfw khayffy kostnr