Resveratrol longevity reddit. Watch David Sinlairs's jre episode for more info on it.
Resveratrol longevity reddit My longevity stack is right now: NR, Quercetin, Berberine and I eat some olive oil for Tyrosol and drink chamomile tea for Apigenin. 128 votes, 97 comments. Members Online • [deleted] ADMIN MOD Matt Kaeberlein: Resveratrol, Fasting, & Rapamycin (with Dr. Joint health: Studies have found that Resveratrol might ease joint pain and reduce inflammation, particularly in conditions like osteoarthritis and rheumatoid arthritis (14). Resveratrol is now PROVEN to do nothing, even being toxic in high doses. Because the natural body's levels of NAD rise in the morning. Resveratrol suppresses the production of hypoxia-inducible factor-1α and vascular endothelial growth factor proteins. This youtube video listed some of the papers related to this topic. /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. Attia also recognizes the potential benefits of resveratrol, primarily for its anti-inflammatory and antioxidant properties. However people that are deep into this stuff such as Dr. nih. Namaskaram, We are a friendly and user-focused community for Redditors from India. Is there anywhere with full coverage on the Resveratrol debate? I saw a video interview recently of Sinclair where he said that the supposed dead-end of Resveratrol was the result of bad science from Pfizer and that recent results from his lab actually suggested Resveratrol's longevity results were real and the mechanism of action worked as they first proposed. ncbi. If you just landed here, feel free to make a post about who you are, why you listen, and what you love about the show. Professor David Sinclair, an anti-aging expert, believes that resveratrol works synergistically with NMN. Valheim; Genshin Impact; Niacin (NA), NMN, NAD+, and other NAD-boosting and longevity health supplements. Or check it out in the app stores Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. Even low doses of resveratrol can activate longevity genes like foxo3a and sirt6. Only charlatans like David Sinclair boost this garbage-- Sinclair is the father of the resveratrol/sirtuin longevity myth and has conflcts of interest ($$$) in its promotion. Oxidative damage: one of the optimized forms of Glutathione and prerostilbene (enhanced bioavailability resveratrol). Such as the longevity “expert” who started a bigger craze around Resveratrol. David Sinclair. At age 50 you have half the nad you had at age 20. That's where the hype comes from. Started One thing Dr S did mention is that resveratrol is, as he called it, a "big, crunchy molecule" and needs fat to be broken down. I got routine bloodwork done a couple of months later to find that my numbers were showing stage 2 or 3 kidney failure (can't recall which). comments sorted From the article: "Dr. Question After about 3 months the resveratrol seems to gives me bloating gas and sometime /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. I just got Mega Resveratrol’s NMN and Resveratrol and I’m stunned (a Prohealth longevity /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. Locked post. Resveratrol activates the SIRT1 "longevity gene" associated with cellular metabolism, cellular repair, and lifespan. Stop trusting experts in mediocre health to tell you what to take. But there are still unsure about evidence. Original work looking for sirt1 activators found resv was best, but quercetin and fisetin do as well Resveratrol might have been overhyped, but then it might have been over-debunked. Thanks for the heads up! Get the Reddit app Scan this QR code to download the app now. nlm. I wouldn't worry about TMG and Resveratrol. Here is more recent article confirming estrogenic activity of resveratrol: https://pubmed. This forum was (originally) created to host articles that were auto-rejected Get the Reddit app Scan this QR code to download the app now. As the video says the stress from alcohol is not good for our bodies. I started taking a small dose of NMN combined with resveratrol. until these modified forms are widely available i think its worth taking in the way prescribed. A subreddit designed for discussion of supplements and nutraceuticals; for Charles Brenner's nonsense about resveratrol is the same nonsense as Brad Stanfield's video: David Sinclair never claimed that resveratrol extended lifespan in healthy people. The youtuber also stopped taking NMN, as NMN will be downgraded to NR before they can be absorbed. He often suggests including it in a comprehensive supplement regimen. There have been a few studies showing a minor decrease in exercise benefit with Resveratrol, but also many dozens of studies showing benefits. One of the key benefits of resveratrol is its potential to prevent the decline in heart function that often comes with aging. It does seem to have an impact on cellular longevity in animal and cellular models, but we still don’t really know the mechanism, and in humans the effects are unclear. The hype was started 15 years ago by David Sinclair, who sold a resveratrol based company to Glaxo and they closed it down, because they couldn't reproduce the results. We were just doing 250mg of nmn and 250mg trans resveratrol a day. Nutritional supplements may be the best tool to support your pet's overall health and performance. Resveratrol - Found in the skin of red grapes, resveratrol is known for its potential to activate certain genes that ward off the diseases of aging. ADMIN MOD I'm updating my longevity stack and I'm taking a hard look at Resveratrol. Resveratrol now seems you should take a much lower dose. Internet Culture (Viral) Amazing; Animals & Pets; Cringe & Facepalm; Funny; Interesting; Memes; Oddly Satisfying; My Glutathione and NAD stack for anti-aging and longevity . Resveratrol has low bioavailability and a low biological halflife. I notice in the study they used an ethanol solution. Read Of course proper nutrition, exercise, sleep, and stress management are the most important factors in health and longevity and should be the priority. Turns out Sinclair's results came out of very amateurish lab mistake, or so he claimed. 347K subscribers in the Supplements community. I’m a healthy 48-year old male. heart disease, and high blood In this study, we investigated whether resveratrol, an activator of an NAD+-dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopenia and cardiomyocyte hypertrophy in mice. Just this week I order my Resveratrol (good source) and I will combine both in the morning & empty stomach. (alive by science), increased to 500 at 2 weeks, then 750 at 3 weeks, 1 g last two days. By activating sirtuins, reducing 153 votes, 162 comments. Day one I played it safe and just took one tablet of each - NMN (125mg) and Resveratrol (415mg) with some fatty yogurt. Too broad of a statement. Resveratrol has gained attention for its potential to extend lifespan in various organisms, primarily through activating certain genes associated with aging. I think you can have those reactions because the NMN like other longevity products works in mitocondria levels. 12 subscribers in the longevit community. (150mg NMN Here we fans discuss the cutting edge of longevity science, the latest episodes, and anything we'd like to see/feedback for the future of the podcast. Looks like Bryan would be taking Resveratrol if it actually attributed to perfect health and longevity. I am actually just getting around to reading Lifespan right now and am considering pulling the trigger on taking NMN But I also listen to Huberman, Attia, and Kyle Gillett who just released a podcast on overrated supplements which included resveratrol Get the Reddit app Scan this QR code to download the app now. me! always read the comments before you use reddit as an excuse to drink! This is thanks to a compound called resveratrol, found in the skin of red grapes used to make wine. I think it's basically about the growth-lonevity tradeoff, MTOR/IGF-1/AMPK, etc. org daily for 9 weeks: 1000 mg NMN + 1000 mg Resveratrol (with yoghurt). The now infamous Sirtris debacle cost a major company 60m USD in purchasing his resveratrol firm and suddenly discovered Get the Reddit app Scan this QR code to download the app now. In fact, for some of the endpoints, it looks like resveratrol made people worse - raising total cholesterol levels and LDL ("bad") cholesterol. Study: Noon time sunlight is less likely to cause skin cancer and much more effective at promoting Vitamin D levels than morning or evening sun. Always been wary of David Sinclair. Brad Stanfield and Siim Land (among others) think Resveratrol is a load of crap. Members Online Discussion of NMN, NR, NAD+, and other longevity molecules as well as topics related to longevity, health, and supplementation. So I'm now on my second bottle of capsules, just one Discussion of NMN, NR, NAD+, and other longevity molecules as well as topics related to longevity, health, and supplementation. edu Open. Omega-3 Fatty Acids - Particularly EPA and Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. Internet Culture (Viral) Amazing Resveratrol's anti-aging benefits have been debunked, its also estrogenic so I stay away. 37:00 - Resveratrol. The data points to the trans-resveratrol and the diet interventions leading to the increased epi age, and the NR decreasing it, unless I Get the Reddit app Scan this QR code to download the app now. Resveratrol needs nad to work but as you age your body produces way less nad. There have been over 100 human studies with Resveratrol. For me it's rule to try minimum 6 months a one suplement and observe the benefits in my body. Don't have recent labs, but judging by my feelings and gym performance, it is working. Members Online David Sinclair offers convincing research that seems to point to the idea that Resveratrol is effective at activating SR1 and increasing longevity. It is a one stop destination to discuss all the news, entertainment, science & technology, sports, history & culture, economy and geopolitics related to India. Brad Stanfield. hms. Please read the sidebar below for our rules. This supplement guide Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. So go see the red cross or I dunno adopt some pet leeches 😂 Health, Performance,Longevity. So I listened to Dr. Anybody have some opinion on what to do with the Resveratrol? Researchers find conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity . The German study they cite re: As a newcomer, resveratrol seems very popular for anti ageing health span and lower mortality rates, and Sinclair talks about its many possible benefits, and have taken it himself for many Resveratrol has been shown to extend lifespan in mice, but only under certain experimental conditions. Longevity and aging: Animal studies suggest that Resveratrol’s antioxidant properties may support healthy aging and promote longevity by reducing cellular damage (15). " Get the Reddit app Scan this QR code to download the app now. I buy all supplements in powder form and add them to one glass water and shot it . Nmn boosts your nad levels. I counteract potential endocrine disruption by taking some other supplements. I would like to know Supplements Resveratrol For Longevity & Immunity: Research & Benefits Resveratrol is a promising compound with significant benefits for ageing and immune health. These Among the polyphenolic phytochemicals, resveratrol is believed to reduce the negative effects of the aging process through its multiple biological activities. In one study, Resveratrol was found to extend lifespan in male mice on a high-calorie, obesogenic diet. Members Online It is popular now to slam Resveratrol because Sinclair made a lot of money selling patents on it, and it didn't work out as a prescription drug for GSK. I did my research and thought hey, there's something to add to my longevity stack. The ITP study repeated David Sinclair's study and found the same outcome: resveratrol did treat fat mice, but not healthy mice. Or check it out in the app stores TOPICS. NMN has been tested by all of them. Members Online New Congressional report proposes scrapping National Institute on Aging One issue is that there are going to be ever-growing amounts of adults over 60. **Duration of Use**: How long have you been taking resveratrol? 2. Members Online Chuck Chan, Stanford stem cell researcher who discovered cells behind cartilage generation, dies at 48 114 subscribers in the longevity2 community. Gaming and other longevity molecules as well as topics related to longevity, health, and supplementation. New comments cannot be posted and votes cannot be cast. Look into nmn as well. " Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. David Sinclair, Dr. I’ll just add, drinking is likely beneficial in smaller doses. And i've come up with a kind of preliminary list of the best supplements to take for longevity based on what pathways they activate and that don't have any proven, bad side effects. We have also tested the effect of a higher dose of resveratrol beginning at 12 months of age (SDHR) on lifespan, and again found that longevity was not significantly affected (Figure 4F). Bryan Johnson takes 500 mg (6x per week). A thought on NMD, Resveratrol and the rest . Definitely don't want to be taking a double-edged sword supplement. The science for resveratrol is embarrassingly thin to negative. Around 125mg every other day with olive oil. Members Online • Sentuivira. A Natural Supplement . Indeed, our EOD feeding regimen was initiated at 12 months of age, and while average lifespan was increased, the effect did not reach statistical significance, except in combination with Then I tried NMN (Nicotinamide Mononucleotide) + Resveratrol from donotage. A medical doctorate is very, very far removed from a PHD and if you want an example of this you can see it by just looking at the differences between similar longevity influencers Peter Attia and David Sinclair. Scientists are not necessarily in agreement about resveratrol being useless. Brad Stanfield) Share Sort by: Best. Watch David Sinlairs's jre episode for more info on it. Not sure if that caused the difference but I have heard Dr S mention more than once that labs getting poor results with resveratrol did not realize it was fat soluble. Resveratrol treatment may be a potential option for infertility therapy. David Sinclair's 8 episode podcast when it was released and started taking resveratrol, quercetin, and fisetin. Taking NMN and resveratrol together has shown to be beneficial. You do not need to follow his stack and I would advise you to research for yourself. Resveratrol acts as an antioxidant, which means it helps protect your body's cells from damage caused by free radicals. As Seen On 60 Minutes . (40 years old, healthy male, exercise regularly and eat a healthy veggie diet). Resveratrol is like a gas pedal and nmn is like the fuel. Is it ok to take both TMG and Resveratrol with my NMN, or should I only be View community ranking In the Top 1% of largest communities on Reddit. Again, I didn’t notice anything happening. In all Some of his research suggested that resveratrol was an activator of sirt1 (homolog of Sir2 in mammals), and Sir2 is implicated in longevity benefits in model organisms that he studies, yeast. Gaming. . Open It seems to me one of the biggest unresolved issues in longevity is diet, and there are a bunch of interrelated debates that probably end up turning on similar questions. Interestingly, researchers found that combining NMN with resveratrol could increase the NAD+ levels in the heart and muscle tissue. Current research that is very promising is modified resveratrol molecules that increase bioavailability. NAD+ and resveratrol supplements may increase longevity, but the research on this is still unclear. Also you really shouldn't equate knowledge of longevity as general medicine or science of the body. Far more have been positive. harvard. Great but Then Dr Brand Stanfield mention that resveratrol don't affect the sirtuins as earlier theorised, and in an interview, Matt Kaeberlein (started in Sinclair lab) is There are lots of evidence showing that the stress resveratrol placed on the cells actually is harmful to them. I stopped taking the metformin and I was fine after a few weeks. Sinclair vs Brenner regarding the anti-aging effects of Resveratrol and NMN This sub is a haven from the flood of misinformation that is Resveratrol and Prostate Cancer – 1 – Resveratrol inhibits cancer by reducing cell proliferation and metastasis and by inducing apoptosis (2012) Resveratrol and Breast Cancer – 2 – Resveratrol suppresses the proliferation of breast cancer cells by inhibiting important signaling pathway (2014) Resveratrol and Colorectal Cancer – Discussion of NMN, NR, NAD+, and other longevity molecules as well as topics related to longevity, health, and supplementation. Members Online I'm on day two of taking NMN & Resveratrol. However, I disagree that Resveratrol is bad for humans. Discussion of NMN, NR, NAD+, and other longevity molecules as well as topics related to longevity, health, and supplementation. One debate is about optimal protein. It can impact a wide variety of areas and cellular signalling pathways, making it difficult to pin down precise benefits. Hopefully this isn't another resveratrol Reddit's main subreddit for videos. So grapes with 20x the amount of resveratrol would be far better than having to take supplements. Internet Culture (Viral) Amazing and other longevity molecules as well as topics related to longevity, health, and supplementation. **Dosage**: What daily dosage (in milligrams) are you currently taking or A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. So, the best way to prevent aging is to consume NMN and resveratrol in the morning. Or check it out in the app stores Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. Resveratrol increases the lifespan of In the context of longevity supplements, I see a lot of posts regarding the amount of NR/NMN one should take daily, but I haven't seen such posts regarding Resveratrol. true Resveratrol increases lifespan in insects via suppressing the effects of Juvenile Hormone receptors; the anti-longevity receptor that antagonizes the effects of ecdysteroid receptors (pro-longevity). New comments cannot be posted. I take trans-resveratrol in high dosage with fat on empty stomach with other sirtuin activators such as berberine, quercetin and tumeric. RESVANTAGE CANINE ® contains resveratrol blended together with a unique combination of nutrients that work synergistically to help him or her reach full potential. It's an expensive supplement and from what I can read it's pretty mixed results. 4 g/kg diet) from 28 weeks of age for 32 weeks prevented aging-associated shortening of rotarod riding time. GSK bought this research via the company Sinclair and other researchers formed around it, with the intent of turning it into a proprietary formulation that they could sell to people, for hundreds The biovailability of resveratrol is incredibly low, so any theoretical benefits it may have cannot be replicated in vivo. If their money is diverted into unproven supplements because of "good safety profiles" while they lack evidence, it's just going to make supplement companies insanely rich, all the while actual research efforts struggle - unless there's a sea change and governments start to wake up to funding priorities The stack I mentioned would be an optimal stack for longevity. Suddenly loads on Reddit from people saying TMG “must” be taken with NMN. Members Online Chuck Chan, Stanford stem cell researcher who discovered cells behind cartilage But i've started to get into age-related/longevity supplements now. Only under some lab conditions resveratrol can activate sirtuin1. I started researching the hell out of things by listening to Dr. gov/32744480/ I also take resveratrol for it's many benefits. Definitely felt a sustained energy lift like I'd had a couple of coffees but not as jittery. Resveratrol exhibits protective activity against hypoxic stress and may prevent hypoxia- or aging- related mitochondrial dysfunction. Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. This forum was (originally) created to host articles that were Discussion of NMN, NR, NAD+, and other longevity molecules as well as topics related to longevity, health, and supplementation. A subreddit about longevity. I took it for longevity for a while. a coworker told me to also take resveratrol with nmn cuz it's supposed to Resveratrol completely bombed in the study. Get the Reddit app Scan this QR code to download the app now. If you do decide to give them a try, I would recommend liposomal versions, since those are likely to provide more benefit at a lower dosage. It's well known that taking certain compounds in isolation can be problematic and the synergistic effects tend to be very beneficial. After 16 weeks of daily resveratrol (oral formulation at a high or low dose), the supplement had not benefit relative to a placebo in any of the tested endpoints. 1. Find news, resources, anecdotes, and research. NMN, Resveratrol, and TMG, along with several others are a stack used by Dr. Peter Attia: Dr. A few have had neutral or slightly negative results. Treatment of mice with resveratrol (0. Members Online /r/longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news. cold exposure (mostly helps with building willpower but has little effects on longevity) peptides (according to the author, most of the available peptides are either useless or unsafe because there is so little data) NMN & resveratrol I can highly recommend reading the full article, the author goes into more depth. And think of resveratrol as a car accelerator, but if you don't have enough gas, you're basically accelerating a car that doesn't have enough gas. Humans do not have Juvenile Hormone to antagonize though, so pro-longevity actions of resveratrol on this hormonal receptor do not apply to mammals. Maybe centro as it primarily protects cell membranes which see more oxidative damage than organelles, but it may be unnecessary/overkill with GSH. Members Online Jeffrey Flier on Sinclair: „I crossed the line by noticing a major piece of his research was untrue, and I expressed concern that he continued to tout it as true to his public audience. Valheim; Genshin Impact; and other longevity molecules as well as topics related to longevity, health, and supplementation. Members Online Dogs could have lifespan extended with promising new drug | Tests in US will see canines given tablet disguised as a sweet treat that scientists claim may expand lifespan with less disease risk Do you take resveratrol? As a newcomer, resveratrol seems very popular for anti ageing health span and lower mortality rates, and Sinclair talks about its many possible benefits, and have taken it himself for many years. Archived post. Is there actually trans-resveratrol in the product? 600mg and 60 capsules of just Resveratrol is not proven to be effective (after decades of study) and has absorption issues. Members Online Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle Posted by u/Longevity_Lifestyle - 1 vote and no comments because it seemed to decrease some early morning inflammation Incidentally I dove down the old-blood-sucks-get-rid-of-your-old-blood rabbit hole the other day and found that donating blood reduces inflammation as well as lowering heart attack and stroke risk. NAD+ Boosters (such as NMN or NR) - Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are precursors to NAD+, a vital coenzyme for various metabolic processes. Rhonda Patrick, and Dr. ufpab ngytzgd tudybqg uivqe xpbq zhwpe yuz kgas xnypt mbs nvod gtukrm iougo kjjqbln plpcw